The Science Behind Sativin & CitruLean
The active ingredients in Sativin and CitruLean are DNF-10® and Sinetrol®, chosen because they are scientifically validated botanical compounds with more than 10 peer-reviewed research studies supporting them.

Shed Pounds, Not Muscle:
The Weight Loss Solution You've Been Waiting For!
You've tried cutting calories, tough workouts, and trendy diets, but the scale barely moves and that belly fat won't quit. Many people turn to GLP-1 medications like semaglutide hoping for real results-only to face a hard truth: while powerful, they often come with nausea, digestive distress, fatigue, loss of muscle, and "Ozempic face." On top of that, many users regain the lost weight within a year of stopping the medication, sometimes mostly as fat.
Lose weight naturally with our Metabolic Boost Bundle. By combining our best-selling Sativin and CitruLeant products and their two patented ingredients: Sinetrol® and DNF-10®. Together, they give you dual-action metabolic support: fat burning and appetite control. There are no injections and no harsh side effects. Just clinically studied ingredients designed to help you lose fat, maintain muscle, and build healthier habits for lasting results.†
Key Health Benefits
Via gut-brain axis modulation, helping prevent overeating without feeling deprived.†
Significant reduction in total body fat and fat mass, specially on abdominal and trunk fat.†
Preserves muscle mass during fat loss — a key advantage over most weight loss methods.†
Provides long-term fat loss as subjects continue to experience adipose beiging. †
Improved lean-to-fat mass ratio and BMI for a balanced physique and better metabolic markers.†
Natural reduction (up to ~600 kcal/day in studies) through enhanced satiety and fewer cravings.†
The active ingredients in Sativin and CitruLean are DNF-10® and Sinetrol®, chosen because they are scientifically validated botanical compounds with more than 10 peer-reviewed research studies supporting them.
The SimpliPur Difference
Clinically Proven Ingredients
The active ingredients have been proven in clinical studies: DNF-10® can reduce caloric intake by 600 kcal, resulting in a 6% fat mass reduction, 5% decrease in abdominal fat after 2 months. Sinetrol® is a fat burner proven to enhance lipolysis, breaking down stored triglycerides into free fatty acids to reduce abdominal fat by 10%.†
Science-Backed
Formulation
Backed by over 10 years of research, the key ingredients - Sinetrol® and DNF-10® - have been proven to be effective in reducing abdominal fat and improving body composition in animal and human clinical studies. Its efficacy is backed by published scientific studies. Their efficacy is backed by over 15 published scientific studies. †
Regulated & Certified
The active ingredients DNF-10® and Sinetrol® are US Patented. Sativin and CitruLean are third-party tested and manufactured in an FDA certified facility. SimpliPur products are Non-GMO Project verified, Halal, gluten-free, and vegetarian. Our products are heat-tested at 160°C/320°F for 30 minutes, offering a stable and safe product for all.†
Quality Manufacturing
Sativin® gummies are manufactured under the highest available standards, in an FDA-certified facility following Good Manufacturing Practices (GMP). We ensure high-quality ingredients, and strict quality control, delivering an effective and safe product you can trust.
Real Customers | Real Results
Your Questions Answered
Sativin® is a weight control dietary supplement that contains DNF-10®, a specially developed proprietary ingredient that suppresses the appetite and reduces caloric intake. It is targeted fat reduction in the midsection and gives you a slimmer body by causing fat loss without the loss of lean muscle mass. †
CitruLean® is a clinically proven fat burner that contains Sinterol®, a citrus extract shown to boost metabolism, enhance fat breakdown, and improve body composition. It helps to target stubborn fat, especially around the trunk area, while sparing lean muscle so that 100% of the weight lost is fat. †
Sativin® works by inhibiting appetite through the gut-brain axis, so you feel fuller and take in fewer calories.
The active ingredient, DNF-10®, is clinically proven to reduce caloric intake, leading to noticeable fat loss. The weight lost is all fat, for a more desirable body composition. †
CitruLean® works by increasing metabolism and increasing fat breakdown in the body, specifically targeting stubborn trunk fat. †
By optimizing fat loss while refining body composition, CitruLean® ensures that any weight loss is fat, not muscle, and the outcome is a healthier, more toned body. †
Most users start noticing a difference within the first few weeks, particularly in reduced waist circumference and abdominal fat. As Sativin® is used longer, the fat loss becomes more noticeable, and long-term benefits are realized with improved body composition and a leaner body. †
Yes, Sativin® is completely safe when used as directed. The active ingredient, DNF-10®, has been extensively tested and has been associated with no side effects. Manufactured in an FDA-approved facility under strict quality control conditions, Sativin® offers a safe, effective way to lose weight.†
With Sativin®, 100% of the weight you lose will be fat. You won't lose muscle, and your body composition will improve as you lose fat, especially around the midsection. You can expect to see a reduction in waist circumference and a leaner, more toned appearance. †
Unlike most fat-loss products, Sativin® selectively acts on fat, especially in difficult areas like the stomach, without sacrificing lean muscle. Its formula, DNF-10®, has been clinically proven to lower caloric intake and aid in sustained fat loss, making it a more effective option for long-term weight management. †
Absolutely! Sativin® is vegetarian, gluten-free, Halal, and Non-GMO. It’s also GRAS (Generally Recognized As Safe) self affirmed, meaning it is deemed safe for consumption by the available scientific evidence. †
Yes! The active ingredient DNF-10® has been backed by over 10 years of research and several clinical trials that confirm its efficiency at suppressing hunger, reducing caloric intake, and enhancing fat burning. These trials provide scientific proof of its efficiency at enhancing body composition and promoting long-term weight loss.
CitruLean® offers various benefits such as:
Fat loss: 100% of the lost weight is from fat. †
Improves body composition: Helps decrease trunk fat, waist, and hip circumference. †
Boosts metabolism: Raises cAMP levels to burn free fatty acids and yield sustained energy. †
Long-term results: Provides long-term metabolic benefits and promotes sustained fat loss. †
Safe and effective: Clinically proven with no reported adverse events from 2008 to 2023. †
Yes, CitruLean® is a safe and effective formula. It is made with high-quality ingredients, like Sinterol®, that have been clinically researched for fat loss.
The product is also manufactured in an FDA-certified facility under Good Manufacturing Practices (GMP), so it is safe and effective.
No adverse events have been reported between 2008 and 2023. †
CitruLean® is one of a kind in that it uses Sinterol®, a scientifically researched citrus extract that selectively targets trunk fat, while sparing lean muscle. Unlike other products available, CitruLean® ensures that 100% of the weight lost is fat, for a healthier body composition without the risk of muscle loss. †
CitruLean® improves body composition by boosting metabolism and the breakdown of fat. It acts on the hard-to-lose fat around the waist and hips, reducing measurements and establishing a healthier lean-to-fat mass ratio, leading to a more balanced and toned body. †
Yes, CitruLean® is clinically tested to burn body fat around the waist and hips. Through its enhancement of fat metabolism and targeting of stubborn fat, CitruLean® reduces waist and hip measurements for a leaner, more toned body. †
Yes, CitruLean® is vegetarian, gluten-free, Halal, and Non-GMO. It is approved by MFDS (Korean FDA) and certified to reduce body fat, offering a compliant and safe product for all. †